| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
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| Autores: |
Galvão,Suzana Maria Pereira
Mendes,Fúlvio Rieli
Oliveira,Maria Gabriela Menezes de
Mattei,Rita
Mello,João Carlos Palazzo de
Roman Júnior,Walter Antonio
Carlini,Elisaldo de Araújo
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| Data: |
2011-12-01
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| Ano: |
2011
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| Palavras-chave: |
Heteropterys aphrodisiaca O. Mach/pharmacognosy
Heteropterys aphrodisiaca O. Mach/antioxidant activity
Malpighiaceae/pharmacognosy
Antioxidants
Flavonoids
Plant extract
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| Resumo: |
Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400020
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000400020
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.4 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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